Luise Wilhelmine Friederike Caroline Auguste Julie was born on 7 September 1817, in Kassel. She was the daughter of Princess Louise Charlotte of Denmark (30 October 1789 - 28 March 1864) and Landgrave William of Hesse-Kassel (24 December 1787 - 5 September 1867). Her maternal grandparents were Sophie Frederikke of Mecklenburg-Schwerin and Prince Frederick of Denmark and Norway. Her paternal grandparents were Princess Caroline of Nassau-Usingen and Prince Frederick of Hesse. Louise married Prince Christian of Schleswig-Holstein-Sonderburg-Glücksburg (8 April 1818 - 29 January 1906) on 26 May 1842, at the Amalienborg Palace, in Copenhagen, Denmark. He was the son of Princess Louise Caroline of Hesse-Kassel (28 September 1789 - 13 March 1867) and Friedrich Wilhelm, Duke of Schleswig-Holstein-Sonderburg-Glücksburg (4 January 1785 - 17 February 1831).
The Children of Louise of Hesse-Kassel and Prince Christian of Schleswig-Holstein-Sonderburg-Glücksburg:
Crown Prince Frederik of Denmark (3 June 1843 - 14 May 1912) Married married Princess Louise Josefina Eugenia of Sweden in 1869.
Princess Alexandra of Denmark (1 December 1844 - 20 November 1925) Married Albert Edward, Prince of Wales in 1863.
Prince Vilhelm of Denmark (24 December 1845 - 18 March 1913)
Princess Dagmar of Denmark (26 November 1847 - 13 October 1928) Married Alexander Alexandrovich in 1866.
Princess Thyra of Denmark (29 September 1853 - 26 February 1933) Married Ernst August of Hanover, 3rd Duke of Cumberland.
Prince Valdemar of Denmark (27 October 1858 - 14 January 1939) Married Princess Marie de Orleáns-Bourbon.
In 1862, she founded Louisestiftelsen. In 1863, her husband became Christian IX, King of Denmark. Her daughter, Alexandra married Albert Edward, Prince of Wales (9 November 1841 -6 May 1910) on 10 March 1863, in St. George's Chapel, Windsor Castle. He was the son of Victoria, Queen of the United Kingdom (24 May 1819 - 22 January 1901) and Prince Albert of Saxe-Coburg-Gotha (26 August 1819-14 December 1861). Her daughter, Dagmar married Grand Duke Alexander Alexandrovich on 9 November 1866, in the Imperial Chapel of the Winter Palace, in St.Petersburg. Dagmar converted to the Russian orthodox faith and was granted the title, Grand Duchess Maria Feodorovna of Russia. Her son, Crown Prince Frederick married Princess Louise Josefina Eugenia of Sweden (31 October 1851 - 20 March 1926) on 28 July 1869, in Stockholm, Sweden. She was the daughter of Louise of the Netherlands, Queen Consort of Sweden and Norway (5 August 1828 - 30 March 1871) and Karl XV & IV, King of Sweden and Norway (3 May 1826 - 18 September 1872). Louise of Hesse-Kassel died aged 81, on 29 September 1898, in Bernstorff Palace, Gentofte, Denmark. Christian IX died on 29 January 1906. He was succeeded by their son as Frederick VIII. Frederick VIII died on 14 May 1912, in Hamburg, Germany. He was buried in Roskilde Cathedral.